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Jobs Available at NYSBC

Jobs Available in the Transcontinental EM Initiative for Membrane Protein Structure

A number of jobs are available in our new NIH-funded PSI center for Membrane Protein Structure Determination (http://temimps.nysbc.org). Our's is the only PSI center exclusively committed to determination of membrane protein structures using electron microscopy. This will involve development of a number of associated technologies, from high-throughput crystallization screening, automated imaging in the electron microscope, novel approaches for image analysis. Our overall goal is to solve structures over the 5-year period of the grant. The target list includes a wide variety of biologically important proteins, including transporters, pumps, signaling molecules, proteases and adhesion proteins.

Electron microscopist at New York University, New York, NY

Postdoctoral position is available immediately for an an electron crystallographer in the laboratory of David Stokes at the Skirball Institute of New York University School of Medicine (http://skirball.med.nyu.edu/~stokes). This position will focus on structure determination of tubular crystals formed by membrane proteins. This work will involve optimization of crystals discovered in the TEMIMPS high-throughput crystallization pipeline, which includes a broad array of novel membrane protein targets (http://temimps.nysbc.org). Structure determination will then involve imaging of frozen-hydrated samples and helical reconstruction using either Fourier Bessel methods or Interative Real Space methods. State-of-the-art cryo-electron microscopes are available both at NYU and at the New York Structural Biology Center for this work. Software for both approaches to helical reconstruction are a development focus for members of the TEMIMPS consortium. Candidate should have a Ph.D. with experience either in electron microscopy or image analysis and an ability to work effectively within the highly collaborative environment of our multi-institutional consortium. To apply, email curriculum vitae and contact information for three professional referees to temimps@nysbc.org or to Dr. David Stokes (stokes@nyu.edu).